Overview

  • Product name

    Anti-Lysosomal acid lipase/LAL antibody
    See all Lysosomal acid lipase/LAL primary antibodies
  • Description

    Mouse polyclonal to Lysosomal acid lipase/LAL
  • Host species

    Mouse
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length protein corresponding to Human Lysosomal acid lipase/LAL. (AAH12287.1)

  • Positive control

    • Human pancreas tissue lysate, Lysosomal acid lipase/LAL transfected 293T cell lysate.
  • General notes

     This product was previously labelled as Lysosomal acid lipase

     

Properties

Applications

Our Abpromise guarantee covers the use of ab89771 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa.

Target

  • Function

    Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
  • Involvement in disease

    Defects in LIPA are the cause of Wolman disease (WOD) [MIM:278000]. WOD is a severe manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. WOD occurs in infancy and is nearly always fatal before the age of 1 year.
    Defects in LIPA are the cause of cholesteryl ester storage disease (CESD) [MIM:278000]. CESD is a mild manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. It is characterized by late-onset.
  • Sequence similarities

    Belongs to the AB hydrolase superfamily. Lipase family.
  • Cellular localization

    Lysosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • Acid cholesteryl ester hydrolase antibody
    • CESD antibody
    • cholesterol ester hydrolase antibody
    • cholesterol ester storage disease antibody
    • Cholesteryl esterase antibody
    • Hydrolase deficiency antibody
    • LAL antibody
    • LAL deficiency cholesterol ester antibody
    • LICH_HUMAN antibody
    • lipA antibody
    • LIPA deficiency antibody
    • Lipase A antibody
    • lipase A, lysosomal acid, cholesterol esterase antibody
    • lysosomal acid lipase antibody
    • lysosomal acid lipase deficiency antibody
    • Lysosomal acid lipase/cholesteryl ester hydrolase antibody
    • Sterol esterase antibody
    see all

Images

  • Anti-Lysosomal acid lipase/LAL antibody (ab89771) at 1 µg/ml + human pancreas tissue lysate at 50 µg

    Predicted band size: 45 kDa
    Observed band size: 45 kDa

  • All lanes : Anti-Lysosomal acid lipase/LAL antibody (ab89771) at 1 µg/ml

    Lane 1 : Lysosomal acid lipase/LAL transfected 293T cell lysate
    Lane 2 : Non-transfected lysate

    Lysates/proteins at 25 µg per lane.

    Predicted band size: 45 kDa
    Observed band size: 45 kDa

References

ab89771 has not yet been referenced specifically in any publications.

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