Overview

  • Product name

  • Description

    Mouse monoclonal to LYST
  • Host species

    Mouse
  • Tested applications

    Suitable for: ELISA, Sandwich ELISAmore details
  • Species reactivity

    Reacts with: Recombinant fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 1-101 of Human LYST with proprietary tag (NP_000072).

  • General notes

    This product was changed from ascites to tissue culture supernatant on 15 May 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

Properties

Applications

Our Abpromise guarantee covers the use of ab118121 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.
Sandwich ELISA Use at an assay dependent concentration.

Target

  • Function

    May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.
  • Tissue specificity

    Abundantly expressed in adult and fetal thymus, peripheral blood leukocytes, bone marrow and several regions of the adult brain.
  • Involvement in disease

    Defects in LYST are the cause of Chediak-Higashi syndrome (CHS) [MIM:214500]. CHS is a rare autosomal recessive disorder characterized by hypopigmentation, severe immunologic deficiency, a bleeding tendency, neurologic abnormalities, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types. Most patients die at an early age unless they receive an allogeneic hematopoietic stem cell transplant (SCT).
  • Sequence similarities

    Contains 1 BEACH domain.
    Contains 7 WD repeats.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • Beige homolog antibody
    • beige protein antibody
    • Chediak-Higashi syndrome 1 antibody
    • CHS antibody
    • CHS1 antibody
    • Lysosomal-trafficking regulator antibody
    • LYST antibody
    • LYST_HUMAN antibody
    • OTTHUMP00000038327 antibody
    see all

Images

  • Detection limit for recombinant tagged LYST is 0.03 ng/ml as a capture antibody.

    This image was generated using the ascites version of the product.

References

ab118121 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab118121.
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