Recombinant Anti-LYVE1 antibody [EPR13067(2)] (ab183501)
![Western blot - Anti-LYVE1 antibody [EPR13067(2)] (ab183501)](https://www.abcam.com/ps/products/183/ab183501/Images/ab183501-214840-anti-lyve1-antibody-epr130672-western-blot.jpg "Western blot - Anti-LYVE1 antibody [EPR13067(2)] (ab183501)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR13067(2)] to LYVE1
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
Overview
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Product name
Anti-LYVE1 antibody [EPR13067(2)]
See all LYVE1 primary antibodies -
Description
Rabbit monoclonal [EPR13067(2)] to LYVE1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide within Human LYVE1 aa 1-100. The exact sequence is proprietary.
Database link: Q9Y5Y7 -
Positive control
- Human tonsil lysate; A549 cell lysate.
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
EPR13067(2) -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab183501 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/1000 - 1/10000. Detects a band of approximately 35 kDa (predicted molecular weight: 35 kDa). |
Target
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Function
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. -
Tissue specificity
Mainly expressed in endothelial cells lining lymphatic vessels. -
Sequence similarities
Contains 1 Link domain. -
Post-translational
modificationsO-glycosylated. -
Cellular localization
Membrane. Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. - Information by UniProt
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Database links
- Entrez Gene: 10894 Human
- Entrez Gene: 114332 Mouse
- Entrez Gene: 293186 Rat
- Omim: 605702 Human
- SwissProt: Q9Y5Y7 Human
- SwissProt: Q8BHC0 Mouse
- Unigene: 655332 Human
- Unigene: 396078 Mouse
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Alternative names
- Cell surface retention sequence-binding protein 1 antibody
- CRSBP 1 antibody
- CRSBP-1 antibody
see all
Images
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Western blot - Anti-LYVE1 antibody [EPR13067(2)] (ab183501)All lanes : Anti-LYVE1 antibody [EPR13067(2)] (ab183501) at 1/5000 dilution
Lane 1 : Human tonsil lysate
Lane 2 : A549 cell lysate
Lysates/proteins at 20 µg per lane.
Secondary
All lanes : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution
Predicted band size: 35 kDa
Observed band size: 35 kDa -
![Anti-LYVE1 antibody [EPR13067(2)] (ab183501)](https://www.abcam.com/ps/products/183/ab183501/Images/ab183501-2-benefits-of-recombinant-antibodies.png)
Anti-LYVE1 antibody [EPR13067(2)] (ab183501)
Datasheets and documents
Certificate of Compliance
References (1)
ab183501 has been referenced in 1 publication.
- Liu X et al. Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels. Acta Neuropathol Commun 8:16 (2020). PubMed: 32059751
