Overview

  • Product name

  • Description

    Rabbit polyclonal to LZTS1/FEZ1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment corresponding to Human LZTS1/FEZ1 aa 315-585.
    Database link: Q9Y250

  • Positive control

    • U87-MG cell lysate; breast cancer tissue
  • General notes

     This product was previously labelled as LZTS1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab127035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 67 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.
  • Tissue specificity

    Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines.
  • Sequence similarities

    Belongs to the LZTS family.
  • Post-translational
    modifications

    Phorphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression.
  • Cellular localization

    Cytoplasm. Cell membrane. Cell projection > dendritic spine. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density.
  • Information by UniProt
  • Database links

  • Alternative names

    • F37 antibody
    • F37/esophageal cancer related gene coding leucine zipper motif antibody
    • F37/esophageal cancer-related gene-coding leucine-zipper motif antibody
    • Fez1 antibody
    • Leucine zipper putative tumor suppressor 1 antibody
    • Lzts1 antibody
    • LZTS1_HUMAN antibody
    • Psdzip70 antibody
    see all

Images

  • Anti-LZTS1/FEZ1 antibody (ab127035) at 1/1000 dilution + U87-MG whole cell lysate at 30 µg

    Predicted band size: 67 kDa



    7.5% SDS PAGE
  • ab127035, at 1/250 dilution, staining LZTS1/FEZ1 in paraffin embedded Human breast cancer tissue.

References

ab127035 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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