Key features and details
- Rabbit polyclonal to LZTS1/FEZ1
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-LZTS1/FEZ1 antibody
See all LZTS1/FEZ1 primary antibodies
DescriptionRabbit polyclonal to LZTS1/FEZ1
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Cow
Recombinant fragment corresponding to Human LZTS1/FEZ1 aa 315-585.
Database link: Q9Y250
- U87-MG cell lysate; breast cancer tissue
This product was previously labelled as LZTS1
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab127035 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 67 kDa.|
|IHC-P||1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionInvolved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.
Tissue specificityHighly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines.
Sequence similaritiesBelongs to the LZTS family.
modificationsPhorphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression.
Cellular localizationCytoplasm. Cell membrane. Cell projection > dendritic spine. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density.
- Information by UniProt
- F37 antibody
- F37/esophageal cancer related gene coding leucine zipper motif antibody
- F37/esophageal cancer-related gene-coding leucine-zipper motif antibody
ab127035 has not yet been referenced specifically in any publications.