Overview

  • Product name

    M 50054, apoptosis inhibitor
  • Description

    Cell-permeable apoptosis inhibitor
  • Biological description

    Cell-permeable apoptosis inhibitor. Inhibits caspase-3 activation and DNA fragmentation. Shows anti-alopecia effects and impedes neuroregeneration in vivo.
  • Purity

    > 95%
  • CAS Number

    54135-60-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[(2,6-Dioxocyclohexyl)methyl]cyclohexane-1,3-dione
  • Molecular weight

    236.26
  • Molecular formula

    C13H16O4
  • PubChem identifier

    2748618
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CC(=O)C(C(=O)C1)CC2C(=O)CCCC2=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Tomizawa M  et al. An Optimal Medium Supplementation Regimen for Initiation of Hepatocyte Differentiation in Human Induced Pluripotent Stem Cells. J Cell Biochem : (2015). Read more (PubMed: 25683148) »
  • Sîrbulescu RF & Zupanc GK Inhibition of caspase-3-mediated apoptosis improves spinal cord repair in a regeneration-competent vertebrate system. Neuroscience 171:599-612 (2010). Read more (PubMed: 20837106) »
  • Tsuda T  et al. Inhibitory effect of M50054, a novel inhibitor of apoptosis, on anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia. Eur J Pharmacol 433:37-45 (2001). Read more (PubMed: 11755132) »

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