Overview

  • Product name

  • Description

    Rabbit polyclonal to M Cadherin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human M Cadherin aa 395-442 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    ATFSAR DPDTEQLQRL SYSKDYDPED WLQVDAATGR IQTQHVLSPA SP


    Database link: P55291

  • Positive control

    • Rat cardiac muscle tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab217861 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

When using a fluorescent probe the recommended dilution is 1/50 – 1/200.

Target

  • Function

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
  • Tissue specificity

    Expressed in the brain and cerebellum.
  • Involvement in disease

    A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24).
    Mental retardation, autosomal dominant 3
  • Sequence similarities

    Contains 5 cadherin domains.
  • Domain

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CAD15_HUMAN antibody
    • Cadherin 14 antibody
    • Cadherin 15 antibody
    • Cadherin 15, type 1, M cadherin (myotubule) antibody
    • Cadherin 3 antibody
    • Cadherin-14 antibody
    • Cadherin-15 antibody
    • Cadherin14 antibody
    • Cadherin15 antibody
    • Cadherin3 antibody
    • CCAD antibody
    • CDH 14 antibody
    • CDH 15 antibody
    • CDH 3 antibody
    • CDH14 antibody
    • Cdh15 antibody
    • CDH3 antibody
    • CDHM antibody
    • M-cadherin antibody
    • MCAD antibody
    • MRD3 antibody
    • Muscle cadherin antibody
    • Myotubule cadherin antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat cardiac muscle tissue labeling M Cadherin with ab217861 at 1/200 dilution, followed Goat Anti-Rabbit IgG, Cy3 conjugated secondary antibody at 1/200 dilution and DAPI staining.

  • Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat cardiac muscle tissue labeling M Cadherin with ab217861 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

References

ab217861 has not yet been referenced specifically in any publications.

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