Anti-MACC1 antibody (ab223710)
Key features and details
- Rabbit polyclonal to MACC1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-MACC1 antibody
See all MACC1 primary antibodies -
Description
Rabbit polyclonal to MACC1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Orangutan -
Immunogen
Recombinant fragment corresponding to Human MACC1 aa 1-100.
Database link: Q6ZN28 -
Positive control
- IHC-P: Human kidney, colon, colorectal cancer and stomach cancer tissue.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), PBS -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab223710 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
|
Notes |
---|
IHC-P
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
-
Function
Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. -
Tissue specificity
Preferentially expressed in metastasizing tumors. -
Sequence similarities
Contains 1 SH3 domain. -
Cellular localization
Cytoplasm. Nucleus. Mainly found in the cytoplasm in non-metastasizing tumors. - Information by UniProt
-
Database links
- Entrez Gene: 346389 Human
- Entrez Gene: 612646 Human
- SwissProt: Q6ZN28 Human
- SwissProt: Q5RBY8 Orangutan
- Unigene: 598388 Human
-
Alternative names
- 7A5 antibody
- MACC1 antibody
- MACC1_HUMAN antibody
see all
Images
-
Paraffin embedded sections of human colorectal cancer were stained for MACC1 with ab223710 at 1/50 dilution in immunohistochemical analysis.
-
Paraffin embedded sections of human stomach cancer were stained for MACC1 with ab223710 at 1/50 dilution in immunohistochemical analysis.
-
Paraffin embedded sections of human colon were stained for MACC1 with ab223710 at 1/50 dilution in immunohistochemical analysis.
-
Paraffin embedded sections of human kidney were stained for MACC1 with ab223710 at 1/50 dilution in immunohistochemical analysis.
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab223710 has not yet been referenced specifically in any publications.