Product nameAnti-MACF1 antibody
See all MACF1 primary antibodies
DescriptionRabbit polyclonal to MACF1
Tested applicationsSuitable for: ICC/IF, WB, ELISAmore details
Species reactivityReacts with: Mouse, Rat
Synthetic peptide corresponding to Mouse MACF1 aa 3651-3846.
KLSPQELT ALREKLHQAK EQYEVLQERT RVAQKELEEA VTSALQQETE KSKAATELAE NKRKIDALLD WVASVGSSER KPQASLPGME QFSGACLEKQ TLAATDGHVD VNQVPETLDR QYELMKARHQ ELLSQQQNFI VATQSVQSFL DQHSHNLTPE ERQKLQEKLG ELKEQYAASL ARSEAELKQT QALRDEL
Database link: Q9QXZ0
- Mouse kidney tissue.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferConstituent: Proprietary component
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab117418 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500. Predicted molecular weight: 832 kDa.|
RelevanceMicrotubule-actin crosslinking factor 1 (MACF1/ACF7) belongs to spectraplakin family of proteins which also includes mammalian Bpag1/dystonin, Drosophila Short Stop (Shot) and Caenorhabditis elegans Vab-10. These are large actin-microtubule linker molecules that are essential for various biological processes such as neuronal degeneration, wound healing, gastrulation. MACF1, located on mouse chromosome 4D2.2, was found to play an important role during neurogenesis- it was shown that MACF1 regulates the organization of neuronal microtubules which is essential for axon extension. Furthermore, MACF1 is required in controlling focal adhesion assembly and dynamics. MACF1 behaves as an actin-regulated ATPase and it has the ability to target microtubules that track along F-actin to focal adhesions. MACF1 was also implicated in regulating filopodia formation.
Cellular localizationCytoplasmic, microtubule. Plasma membrane. Golgi apparatus.
- ABP620 antibody
- Acf7 antibody
- Aclp7 antibody
ab117418 has not yet been referenced specifically in any publications.