Overview

  • Product name
    Anti-Macrophage antibody [PM-2K] (Biotin)
    See all Macrophage primary antibodies
  • Description
    Mouse monoclonal [PM-2K] to Macrophage (Biotin)
  • Host species
    Mouse
  • Conjugation
    Biotin
  • Specificity
    Does not recognize Macrophage Scavenger Receptor AI or AII as determined using positive CHO cells.
  • Tested applications
    Suitable for: IHC-Frmore details
  • Species reactivity
    Reacts with: Cow, Cat, Dog, Human, Pig, Monkey
    Does not react with: Rat, Rabbit, Goat, Horse, Guinea pig, Hamster

Properties

Applications

Our Abpromise guarantee covers the use of ab177226 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/1000.

Target

  • Relevance
    Macrophages comprise of many forms of mononuclear phagocytes found in tissues. Mononuclear phagocytes arise from hematopoietic stem cells in the bone marrow. After passing through the monoblast and promonocyte states of the monocyte stage, they enter the blood, where they circulate for about 40 hours. They then enter tissues and increase in size, phagocytic activity, and lysosomal enzyme content becomming macrophages. Among the functions of macrophages are nonspecific phagocytosis and pinocytosis, specific phagocytosis of opsonized microorganisms mediated by Fc receptors and complement receptors, killing of ingested microorganisms, digestion and presentation of antigens to T and B lymphocytes, and secretion of a large number of diverse products, including many enzymes including lysozyme and collagenases, several complement components and coagulation factors, some prostaglandins and leukotrienes, and many regulatory molecules (Interferon, Interleukin 1). Among cells that are now recognised as macrophages are histiocytes, Kupffer cells, osteoclasts, microglial cells, synovial type A cells, interdigitating cells, and Langerhans cells (in normal tissues) and epithelioid cells and Langerhans-type and foreign-body-type multinucleated giant cells (in inflamed tissues).
  • Alternative names
    • macrophages antibody

References

This product has been referenced in:
  • Zhang H  et al. Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer. Blood 122:1105-13 (2013). Read more (PubMed: 23757729) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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