Anti-Macrophage Inflammatory Protein 3 alpha antibody (ab25123)
Key features and details
- Rabbit polyclonal to Macrophage Inflammatory Protein 3 alpha
- Suitable for: WB
- Isotype: IgG
Overview
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Product name
Anti-Macrophage Inflammatory Protein 3 alpha antibody
See all Macrophage Inflammatory Protein 3 alpha primary antibodies -
Description
Rabbit polyclonal to Macrophage Inflammatory Protein 3 alpha -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Immunogen
E.coli expressed recombinant fragment: MACKHLPFLA LAGVLLAYL CSQSEAASN FDCCLTYTK NVYHHARNF VGFTTQMAD EACDINAII, corresponding to N terminal amino acids 1-70 of Rat Macrophage Inflammatory Protein 3 alpha
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.20
Preservative: 0.1% Sodium azide
Constituent: 99.9% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab25123 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/2000. Predicted molecular weight: 11 kDa.
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Notes |
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WB
1/2000. Predicted molecular weight: 11 kDa. |
Target
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Function
Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. -
Tissue specificity
Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon. -
Sequence similarities
Belongs to the intercrine beta (chemokine CC) family. -
Post-translational
modificationsC-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes. -
Cellular localization
Secreted. - Information by UniProt
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Alternative names
- Beta chemokine exodus 1 antibody
- Beta-chemokine exodus-1 antibody
- C C motif chemokine ligand 20 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab25123 has been referenced in 2 publications.
- Krebs R et al. Critical role of VEGF-C/VEGFR-3 signaling in innate and adaptive immune responses in experimental obliterative bronchiolitis. Am J Pathol 181:1607-20 (2012). PubMed: 22959907
- Qi W et al. High glucose induces macrophage inflammatory protein-3 alpha in renal proximal tubule cells via a transforming growth factor-beta 1 dependent mechanism. Nephrol Dial Transplant 22:3147-53 (2007). PubMed: 17664181