Key features and details
- Mouse polyclonal to Mad2L2/REV7
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Mad2L2/REV7 antibody
See all Mad2L2/REV7 primary antibodies
DescriptionMouse polyclonal to Mad2L2/REV7
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Cow
Full length protein corresponding to Human Mad2L2/REV7 aa 1-211. (AAH15244.1)
MTTLTRQDLNFGQVVADVLCEFLEVAVHLILYVREVYPVGIFQKRKKYNV PVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVF EITQPPLLSISSDSLLSHVEQLLRAFILKISVCDAVLDHNPPGCTFTVLV HTREAATRNMEKIQVIKDFPWILADEQDVHMHDPRLIPLKTMTSDILKMQ LYVEERAHKGS
- Mad2L2/REV7 transfected 293T cell lysate.
This product was previously labelled as Mad2L2
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferpH: 7.20
Constituent: 99% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab168660 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 24 kDa.|
FunctionAdapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
Tissue specificityUbiquitously expressed.
Sequence similaritiesContains 1 HORMA domain.
Cellular localizationNucleus. Cytoplasm > cytoskeleton > spindle. Cytoplasm.
- Information by UniProt
- Homolog of REV7 S cerevisiae antibody
- hREV7 antibody
- MAD2 (mitotic arrest deficient yeast, homolog) like 2 antibody
ab168660 has not yet been referenced specifically in any publications.