Overview

  • Product name

    Madecassic acid, triterpenoid compound
  • Description

    Triterpenoid compound extracted from Centella asiatica with multiple biological activites
  • Biological description

    Triterpenoid compound extracted from Centella asiatica with multiple biological activites. Non-competive cytochrome P450 (CYP) inhibitor (Ki values are 34.1 and 49.7µM for CYP2C9 and CYP2D6 respectively). Inhibits LPS-induced NFκB activity. Anti-inflammatory, wound healing and anti-oxidant reagent. Active in vivo.
  • Purity

    > 95%
  • CAS Number

    18449-41-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1S,2R,4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-Trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
  • Molecular weight

    504.70
  • Molecular formula

    C30H48O6
  • PubChem identifier

    73412
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CCC2(CCC3(C(=CCC4C3(CC(C5C4(CC(C(C5(C)CO)O)O)C)O)C)C2C1C)C)C(=O)O
  • Source

    Centella asiatica

  • Research areas

References

This product has been referenced in:

  • Yin MC  et al. Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice. J Agric Food Chem 60:7697-701 (2012). Read more (PubMed: 22816768) »
  • Hashim P  et al. Triterpene composition and bioactivities of Centella asiatica. Molecules 16:1310-22 (2011). Read more (PubMed: 21278681) »
  • Won JH  et al. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells. Planta Med 76:251-7 (2010). Read more (PubMed: 19774506) »
  • Pan Y  et al. In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica. J Ethnopharmacol 130:275-83 (2010). Read more (PubMed: 20457244) »

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