Overview

  • Product name

  • Description

    Rabbit polyclonal to MAEA
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Cow, Xenopus laevis, Zebrafish, Xenopus tropicalis
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 169-396 of Human MAEA

  • Positive control

    • HCT116 cell line; HepG2 whole cell lysate (ab7900); HeLa cells

Properties

Applications

Our Abpromise guarantee covers the use of ab151304 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 45 kDa.
ICC/IF 1/100 - 1/1000. Methanol fixed.

Target

  • Function

    Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.
  • Tissue specificity

    Ubiquitous.
  • Sequence similarities

    Contains 1 CTLH domain.
    Contains 1 LisH domain.
  • Developmental stage

    Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis.
  • Cellular localization

    Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Localized as nuclear speckled-like pattern.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1110030D19Rik antibody
    • Cell proliferation inducing gene 5 protein antibody
    • Cell proliferation-inducing gene 5 protein antibody
    • EMLP antibody
    • EMP antibody
    • Erythroblast macrophage protein antibody
    • GID complex subunit 9 FYV10 homolog antibody
    • GID9 antibody
    • HLC 10 antibody
    • HLC-10 antibody
    • HLC10 antibody
    • Human lung cancer oncogene 10 protein antibody
    • Lung cancer related protein 10 antibody
    • Macrophage erythroblast attacher antibody
    • MAEA antibody
    • MAEA_HUMAN antibody
    • MGC93683 antibody
    • PIG5 antibody
    • Proliferation inducing gene 5 antibody
    see all

Images

  • Anti-MAEA antibody (ab151304) at 1/5000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size: 45 kDa



    10% SDS PAGE
  • Immunofluorescent analysis using confocal microscopy of methanol-fixed HeLa cells labeling MAEA with ab151304 antibody at 1/500 dilution (Green). Alpha-tubulin filaments were labeled in Red.

References

This product has been referenced in:

  • Salemi LM  et al. Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex. BMC Cancer 17:460 (2017). Read more (PubMed: 28668087) »
See 1 Publication for this product

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