Overview

  • Product name

  • Description

    Rabbit polyclonal to MAGEA1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human MAGEA1 (internal sequence). The exact sequence is proprietary.
    Database link: P43355

  • Positive control

    • WB: MCF7 whole cell lysate. ICC/IF: A-375 cells.
  • General notes

     This product was previously labelled as MAGE 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab228591 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 34 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function

    May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
  • Tissue specificity

    Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.
  • Sequence similarities

    Contains 1 MAGE domain.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Antigen MZ2 E antibody
    • Antigen MZ2-E antibody
    • Cancer/testis antigen 1.1 antibody
    • cancer/testis antigen family 1, member 1 antibody
    • CT1.1 antibody
    • MAGA1_HUMAN antibody
    • MAGE 1 antigen antibody
    • MAGE-1 antigen antibody
    • MAGE1 antibody
    • MAGE1A antibody
    • MAGEA1 antibody
    • Melanoma antigen 1 antibody
    • Melanoma antigen family A 1 (directs expression of antigen MZ2 E) antibody
    • Melanoma antigen family A 1 antibody
    • Melanoma antigen MAGE 1 antibody
    • Melanoma associated antigen 1 antibody
    • Melanoma associated antigen MZ2 E antibody
    • Melanoma-associated antigen 1 antibody
    • MGC9326 antibody
    see all

Images

  • Anti-MAGEA1 antibody (ab228591) at 1/1000 dilution + MCF7 (human breast adenocarcinoma cell line) whole cell lysate at 30 µg

    Predicted band size: 34 kDa



    10% SDS-PAGE gel.

  • A-375 (human malignant melanoma cell line) cells stained for MAGEA1 (green) using ab228591 at 1/500 dilution in ICC/IF. Cells were fixed in 4% paraformaldehyde at RT for 15 minutes.

    Nuclear counter stain: Hoechst 33342 (blue).

References

ab228591 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab228591.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up