Anti-MAGED1/NRAGE antibody (ab104627)
Key features and details
- Rabbit polyclonal to MAGED1/NRAGE
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
Overview
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Product name
Anti-MAGED1/NRAGE antibody
See all MAGED1/NRAGE primary antibodies -
Description
Rabbit polyclonal to MAGED1/NRAGE -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat
Predicted to work with: Human -
Immunogen
Synthetic peptide corresponding to Mouse MAGED1/NRAGE aa 683-699 conjugated to keyhole limpet haemocyanin.
Sequence:C-EAEARAEARNRMGIGDE
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Positive control
- PC12 cell extracts
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab104627 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 86 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 86 kDa. |
Target
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Function
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. -
Tissue specificity
Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed. -
Sequence similarities
Contains 1 MAGE domain. -
Cellular localization
Cytoplasm. Cell membrane. Nucleus. Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. - Information by UniProt
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Database links
- Entrez Gene: 9500 Human
- Entrez Gene: 84469 Rat
- Omim: 300224 Human
- SwissProt: Q9Y5V3 Human
- SwissProt: Q9ES73 Rat
- Unigene: 5258 Human
- Unigene: 54596 Rat
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Alternative names
- DLXIN 1 antibody
- MAGD1_HUMAN antibody
- MAGE D1 antigen antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab104627 has not yet been referenced specifically in any publications.