Magnolol (5,5'-Diallyl-2,2'-dihydroxybiphenyl), antioxidant (ab142443)

Overview

  • Product name

    Magnolol (5,5'-Diallyl-2,2'-dihydroxybiphenyl), antioxidant
  • Description

    Potent antioxidant. Anti-inflammatory and apoptotic agent.
  • Biological description

    Potent antioxidant. Inhibits iNOS expression (IC50 = 16.8 μM). Anti-inflammatory, antioxidative, antitumor, antimicrobial and apoptotic agent. Induces apoptosis by upregulating p53 and bax expression. Honokiol (Asc 647) isomer. Inhibits LPS-induced TNF-α and IL-1β production. Antidepressant and anxiolytic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    528-43-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ho JH & Hong CY Cardiovascular protection of magnolol: cell-type specificity and dose-related effects. J Biomed Sci 19:70 (2012). Read more (PubMed: 22849814) »
  • Park JB  et al. Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway. Biol Pharm Bull 35:1614-20 (2012). Read more (PubMed: 22975518) »
  • Ni YF  et al. Protective effect of magnolol on lipopolysaccharide-induced acute lung injury in mice. Inflammation 35:1860-6 (2012). Read more (PubMed: 23053725) »

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