Overview

  • Product name

  • Description

    Rabbit polyclonal to MAL2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Rat, Human
  • Immunogen

    Synthetic peptide within Human MAL2 aa 10-60 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    PPPNPAVSFPP PRVTLPAGPD ILRTYSGAFV CLEILFGGLV WILVASSNVP


    Database link: Q969L2

  • Positive control

    • Mouse lung tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab217919 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Target

  • Function

    Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.
  • Tissue specificity

    Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine.
  • Sequence similarities

    Belongs to the MAL family.
    Contains 1 MARVEL domain.
  • Cellular localization

    Cell membrane. Apical cell membrane. Endomembrane system. Cytoplasm > perinuclear region. Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma HepG2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized HepG2 cells, distributed to the perinuclear region.
  • Information by UniProt
  • Database links

  • Alternative names

    • MAL 2 antibody
    • MAL proteolipid protein 2 antibody
    • Mal, T cell differentiation protein 2 antibody
    • mal2 antibody
    • MAL2_HUMAN antibody
    • Protein MAL2 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed and paraffin embedded mouse lung tissue labeling MAL2 with ab217919 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

References

ab217919 has not yet been referenced specifically in any publications.

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