Key features and details
- Rabbit polyclonal to MAL2
- Suitable for: ELISA, ICC, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-MAL2 antibody
See all MAL2 primary antibodies
DescriptionRabbit polyclonal to MAL2
Tested applicationsSuitable for: ELISA, ICC, WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide derived from the N-terminal domain of human MAL2
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferConstituent: Whole serum
Concentration information loading...
Our Abpromise guarantee covers the use of ab75347 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||Use at an assay dependent concentration.|
|ICC||1/50 - 1/200.|
|WB||1/200 - 1/1000. Predicted molecular weight: 19 kDa.|
FunctionMember of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.
Tissue specificityPredominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine.
Sequence similaritiesBelongs to the MAL family.
Contains 1 MARVEL domain.
Cellular localizationCell membrane. Apical cell membrane. Endomembrane system. Cytoplasm > perinuclear region. Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma HepG2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized HepG2 cells, distributed to the perinuclear region.
- Information by UniProt
- MAL 2 antibody
- MAL proteolipid protein 2 antibody
- Mal, T cell differentiation protein 2 antibody
ab75347 has been referenced in 3 publications.
- Lamm KYB et al. Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome. Elife 7:N/A (2018). PubMed: 29309034
- Li J et al. The four-transmembrane protein MAL2 and tumor protein D52 (TPD52) are highly expressed in colorectal cancer and correlated with poor prognosis. PLoS One 12:e0178515 (2017). IHC-P ; Human . PubMed: 28562687
- Katz E et al. An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer. PLoS One 6:e17083 (2011). WB . PubMed: 21347235