Overview

  • Product name

    Malformin C, cell cycle G2 arrest inhibitor
  • Description

    Highly potent cell cycle G2 arrest inhibitor
  • Biological description

    Highly potent cell cycle G2 arrest inhibitor (IC50 = 0.9 nM, Bleomycin (ab142406, ab142977)-induced G2 arrest in Jurkat cells). Induces root curvature and enhances fibrinolytic activity in plants in vivo.
  • Purity

    > 97%
  • CAS Number

    59926-78-2
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    529.72
  • Molecular formula

    C23H39N5O5S2
  • Sequence

    Cyclo(CVLLC) (Modifications: Cys-1 = D-Cys, Leu-3 = D-Leu, Cys-5 = D-Cys, Disulfide bridge: 1-5)
  • PubChem identifier

    23983656
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sørensen LM  et al. Proteome analysis of Aspergillus niger: lactate added in starch-containing medium can increase production of the mycotoxin fumonisin B2 by modifying acetyl-CoA metabolism. BMC Microbiol 9:255 (2009). Read more (PubMed: 20003296) »
  • Kojima Y  et al. Total synthesis of malformin C, an inhibitor of bleomycin-induced G2 arrest. J Antibiot (Tokyo) 61:297-302 (2008). Read more (PubMed: 18653995) »
  • Hagimori K  et al. Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells. Biol Pharm Bull 30:1379-83 (2007). Read more (PubMed: 17666789) »

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