Product nameAnti-Malondialdehyde antibody
See all Malondialdehyde primary antibodies
DescriptionGoat polyclonal to Malondialdehyde
SpecificityThis antibody specifically binds to Malondialdehyde LDL and other MDA modified proteins.
Tested applicationsSuitable for: ELISA, WB, Conjugationmore details
Chemical/ Small Molecule MDA modified protein
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 0.2% PBS, 0.0292% EDTA, 0.435% Sodium chloride, 30% Glycerol
Concentration information loading...
Purification notesThis antibody was purified by Malondialdehyde modified protein Sepharose affinity column.
Our Abpromise guarantee covers the use of ab27644 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||1/2500 - 1/20000.|
|WB||1/2500 - 1/20000.|
|Conjugation||Use at an assay dependent dilution.|
RelevanceMalondialdehyde (MDA) is a natural product formed in all mammalian cells as a product of lipid peroxidation. MDA is a highly reactive three carbon dialdehyde produced as a byproduct of polyunsaturated fatty acid peroxidation and arachidonic acid metabolism. MDA readily combines with several functional groups on molecules including proteins, lipoproteins, and DNA. It reacts with DNA to form adducts to deoxyguanosine and deoxyadenosine. The major adduct to DNA is a pyrimidopurinone called M1G which appears to be a major endogenous DNA adduct in human beings that may contribute significantly to cancer linked to lifestyle and dietary factors. MDA modified proteins may show altered physico chemical behavior and antigenicity. MDA is toxic and has been implicated in aging mutagenesis, carcinogenesis, diabetic nephropathy and radiation damage. Increased expression of MDA has been reported in the brains of Alzheimer's patients. Antibodies to MDA will help to visualize the MDA adducts.
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This product has been referenced in:
- Coliva G et al. Impact of inhibition of the autophagy-lysosomal pathway on biomolecules carbonylation and proteome regulation in rat cardiac cells. Redox Biol N/A:101123 (2019). Read more (PubMed: 30737170) »
- Li H et al. Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus. J Clin Invest 125:2877-90 (2015). Read more (PubMed: 26098211) »