Key features and details
- Goat polyclonal to Malondialdehyde (FITC)
- Suitable for: ICC/IF
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG
Product nameAnti-Malondialdehyde antibody (FITC)
See all Malondialdehyde primary antibodies
DescriptionGoat polyclonal to Malondialdehyde (FITC)
ConjugationFITC. Ex: 493nm, Em: 528nm
SpecificityThis antibody specifically binds to Malondialdehyde.
Tested applicationsSuitable for: ICC/IFmore details
Chemical/ Small Molecule MDA modified protein
Molar FITC/ Protein ratio is 3.1
Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 0.2% PBS, 0.0146% EDTA, 0.435% Sodium chloride, 0.5% BSA, 30% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Purification notesPurified by Malondialdehyde modified protein-Sepharose™ affinity column.
Our Abpromise guarantee covers the use of ab27615 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use at an assay dependent dilution.|
RelevanceMalondialdehyde (MDA) is a natural product formed in all mammalian cells as a product of lipid peroxidation. MDA is a highly reactive three carbon dialdehyde produced as a byproduct of polyunsaturated fatty acid peroxidation and arachidonic acid metabolism. MDA readily combines with several functional groups on molecules including proteins, lipoproteins, and DNA. It reacts with DNA to form adducts to deoxyguanosine and deoxyadenosine. The major adduct to DNA is a pyrimidopurinone called M1G which appears to be a major endogenous DNA adduct in human beings that may contribute significantly to cancer linked to lifestyle and dietary factors. MDA modified proteins may show altered physico chemical behavior and antigenicity. MDA is toxic and has been implicated in aging mutagenesis, carcinogenesis, diabetic nephropathy and radiation damage. Increased expression of MDA has been reported in the brains of Alzheimer's patients. Antibodies to MDA will help to visualize the MDA adducts.
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To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab27615 has not yet been referenced specifically in any publications.