Overview

  • Product name

    Anti-MALT1/MLT antibody [MT1/410]
    See all MALT1/MLT primary antibodies
  • Description

    Mouse monoclonal [MT1/410] to MALT1/MLT
  • Host species

    Mouse
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human MALT1/MLT aa 701-808.
    Sequence:

    DKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHY HSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSR SNVPVETT


    Database link: Q9UDY8

  • Positive control

    • Human tonsil and lymphoma tissues; Daudi cell lysate; Jurkat, Daudi and HeLa cells.
  • General notes

     This product was previously labelled as MALT1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab178581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 92 kDa.
IHC-P 1/200 - 1/400. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

(Primary incubation for 30 minutes at RT)
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.

Target

  • Function

    Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.
  • Tissue specificity

    Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
  • Involvement in disease

    Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
  • Sequence similarities

    Belongs to the peptidase C14B family.
    Contains 1 death domain.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Cellular localization

    Cytoplasm > perinuclear region. Nucleus. Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.
  • Information by UniProt
  • Database links

  • Alternative names

    • Caspase like protein antibody
    • DKFZp434L132 antibody
    • IMD12 antibody
    • MALT 1 antibody
    • MALT associated translocation antibody
    • MALT lymphoma associated translocation antibody
    • MALT lymphoma-associated translocation antibody
    • Malt1 antibody
    • MALT1 paracaspase antibody
    • MALT1_HUMAN antibody
    • MLT 1 antibody
    • MLT antibody
    • MLT1 antibody
    • Mucosa associated lymphoid tissue lymphoma translocation gene 1 antibody
    • Mucosa associated lymphoid tissue lymphoma translocation protein 1 antibody
    • Mucosa-associated lymphoid tissue lymphoma translocation protein 1 antibody
    • Paracaspase antibody
    • Paracaspase-1 antibody
    • PCASP1 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling MALT1/MLT with ab178581 at 1/200 dilution followed by peroxidase-conjugate and DAB chromogen.

  • Anti-MALT1/MLT antibody [MT1/410] (ab178581) + Daudi cell lysate

    Predicted band size: 92 kDa

References

ab178581 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab178581.
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