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Epigenetics and Nuclear Signaling Transcription Other factors
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Anti-MAML2 antibody (ab90592)

  • Datasheet
  • SDS
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAML2 antibody (ab90592)

    Key features and details

    • Rabbit polyclonal to MAML2
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-MAML2 antibody
      See all MAML2 primary antibodies
    • Description

      Rabbit polyclonal to MAML2
    • Host species

      Rabbit
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Rabbit, Horse, Guinea pig, Cow, Dog, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Orangutan
    • Immunogen

      Synthetic peptide, corresponding to a region between residue 1100 and the C-terminus (residue 1153) of Human MAML2 (AAK93831.1).

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
    • Storage buffer

      pH: 6.8
      Preservative: 0.09% Sodium azide
      Constituents: Tris buffered saline, 0.1% BSA
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Epigenetics and Nuclear Signaling
      • Transcription
      • Other factors
      • Stem Cells
      • Signaling Pathways
      • Notch
      • Nuclear
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Co-factors

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab90592 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    1/100 - 1/500.

    Epitope exposure is recommended. Epitope exposure with Tris-EDTA pH9.0 buffer will enhance staining.

    Notes
    IHC-P
    1/100 - 1/500.

    Epitope exposure is recommended. Epitope exposure with Tris-EDTA pH9.0 buffer will enhance staining.

    Target

    • Function

      Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
    • Tissue specificity

      Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle.
    • Involvement in disease

      Note=A chromosomal aberration involving MAML2 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with CRTC1/MECT1. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.
    • Sequence similarities

      Belongs to the mastermind family.
    • Domain

      The C-terminal domain is required for transcriptional activation.
    • Cellular localization

      Nucleus speckle. Nuclear, in a punctate manner.
    • Target information above from: UniProt accession Q8IZL2 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 84441 Human
      • Omim: 607537 Human
      • SwissProt: A5D7F6 Cow
      • SwissProt: Q8IZL2 Human
      • Unigene: 428214 Human
      • Alternative names

        • KIAA1819 antibody
        • Mam 2 antibody
        • Mam-2 antibody
        • MAML2 antibody
        • MAML2_HUMAN antibody
        • Mastermind-like protein 2 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAML2 antibody (ab90592)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAML2 antibody (ab90592)
        ab90592, at 1/250 dilution, staining MAML2 in formalin-fixed, paraffin-embedded Human stomach carcinoma by Immunohistochemistry, using DAB detection.

      Protocols

      • Immunohistochemistry protocols
      • Immunocytochemistry & immunofluorescence protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (2)

      Publishing research using ab90592? Please let us know so that we can cite the reference in this datasheet.

      ab90592 has been referenced in 2 publications.

      • Liu HT  et al. Nanoparticulated Honokiol Mitigates Cisplatin-Induced Chronic Kidney Injury by Maintaining Mitochondria Antioxidant Capacity and Reducing Caspase 3-Associated Cellular Apoptosis. Antioxidants (Basel) 8:N/A (2019). PubMed: 31600935
      • Lim ML  et al. Characterization of stem-like cells in mucoepidermoid tracheal paediatric tumor. PLoS One 9:e107712 (2014). ICC/IF ; Human . PubMed: 25229469

      Customer reviews and Q&As

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