Anti-MAML2 antibody (ab90592)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAML2 antibody (ab90592)

    Key features and details

    • Rabbit polyclonal to MAML2
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-MAML2 antibody
      See all MAML2 primary antibodies

    • Description

      Rabbit polyclonal to MAML2

    • Host species

      Rabbit

    • Tested applications

      Suitable for: IHC-Pmore details

    • Species reactivity

      Reacts with: Human
      Predicted to work with: Rabbit, Horse, Guinea pig, Cow, Dog, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Orangutan

    • Immunogen

      Synthetic peptide, corresponding to a region between residue 1100 and the C-terminus (residue 1153) of Human MAML2 (AAK93831.1).

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab90592 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    1/100 - 1/500.

    Epitope exposure is recommended. Epitope exposure with Tris-EDTA pH9.0 buffer will enhance staining.
    Notes
    IHC-P
    1/100 - 1/500.

    Epitope exposure is recommended. Epitope exposure with Tris-EDTA pH9.0 buffer will enhance staining.

    Target

    • Function

      Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.

    • Tissue specificity

      Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle.

    • Involvement in disease

      Note=A chromosomal aberration involving MAML2 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with CRTC1/MECT1. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.

    • Sequence similarities

      Belongs to the mastermind family.

    • Domain

      The C-terminal domain is required for transcriptional activation.

    • Cellular localization

      Nucleus speckle. Nuclear, in a punctate manner.
    • Information by UniProt

    • Database links

      • Alternative names

        • KIAA1819 antibody
        • Mam 2 antibody
        • Mam-2 antibody
        • MAML2 antibody
        • MAML2_HUMAN antibody
        • Mastermind-like protein 2 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAML2 antibody (ab90592)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAML2 antibody (ab90592)
        ab90592, at 1/250 dilution, staining MAML2 in formalin-fixed, paraffin-embedded Human stomach carcinoma by Immunohistochemistry, using DAB detection.

      References (2)

      Publishing research using ab90592? Please let us know so that we can cite the reference in this datasheet.

      ab90592 has been referenced in 2 publications.

      • Liu HT  et al. Nanoparticulated Honokiol Mitigates Cisplatin-Induced Chronic Kidney Injury by Maintaining Mitochondria Antioxidant Capacity and Reducing Caspase 3-Associated Cellular Apoptosis. Antioxidants (Basel) 8:N/A (2019). PubMed: 31600935
      • Lim ML  et al. Characterization of stem-like cells in mucoepidermoid tracheal paediatric tumor. PLoS One 9:e107712 (2014). ICC/IF ; Human . PubMed: 25229469

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