• Product name
  • Description
    Rabbit polyclonal to MAN1
  • Host species
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to 18 amino acids near the C-terminus of Human MAN1 (NP_055134).

  • Positive control
    • Human colon tissue lysate



Our Abpromise guarantee covers the use of ab124148 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 100 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.


  • Function
    Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.
  • Tissue specificity
    Heart, brain, placenta, lung, liver and skeletal muscle.
  • Involvement in disease
    Defects in LEMD3 are the cause of Buschke-Ollendorff syndrome (BOS) [MIM:166700]; also known as dermatoosteopoikilosis or disseminated dermatofibrosis with osteopoikilosis or dermatofibrosis lenticularis disseminata with osteopoikilosis or osteopathia condensans disseminata. BOS refers to the association of osteopoikilosis with disseminated connective-tissue nevi. Osteopoikilosis is a skeletal dysplasia characterized by a symmetric but unequal distribution of multiple hyperostotic areas in different parts of the skeleton. Both elastic-type nevi (juvenile elastoma) and collagen-type nevi (dermatofibrosis lenticularis disseminata) have been described in BOS. Skin or bony lesions can be absent in some family members, whereas other relatives may have both.
    Defects in LEMD3 are a cause of melorheostosis (MEL) [MIM:155950]. Melorheostosis is a rare mesenchymal dysplasia and one of the sclerosing bone disorders. It is caused by a developmental error, with a sclerotomal distribution, frequently involving one limb. It may be asymptomatic, but pain, stiffness with limitation of motion, leg-length discrepancy and limb deformity may occur.
  • Sequence similarities
    Contains 1 LEM domain.
  • Cellular localization
    Nucleus inner membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Inner nuclear membrane protein Man1 antibody
    • LEM domain containing protein 3 antibody
    • LEM domain-containing protein 3 antibody
    • LEMD3 antibody
    • MAN1_HUMAN antibody
    see all


  • Anti-MAN1 antibody (ab124148) at 2 µg/ml + Human colon tissue lysate at 15 µg

    Predicted band size: 100 kDa

  • Immunohistochemical analysis of Human colon tissue, staining MAN1 with ab124148 at 2.5 µg/ml.


ab124148 has not yet been referenced specifically in any publications.

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