Overview

  • Product name

    Manidipine dihydrochloride, calcium channel blocker
  • Description

    Potent calcium channel blocker
  • Biological description

    Potent calcium channel blocker (IC50 = 2.6 nM). Suppresses proliferation and stimulates glycosaminoglycan synthesis in vitro. Antihypertensive agent. Orally active. Active in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    89226-75-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-O-[2-(4-Benzhydrylpiperazin-1-yl)ethyl]-3-O-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
  • Molecular weight

    683.62
  • Molecular formula

    C35H38N4O6.2HCl
  • PubChem identifier

    150762
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO, water and ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC.Cl.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Tohse N  et al. Voltage-dependent modulation of L-type Ca2+ current by manidipine in guinea-pig heart cells. Eur J Pharmacol 249:231-3 (1993). Read more (PubMed: 8287905) »
  • Tojo A  et al. Effects of manidipine hydrochloride on the renal microcirculation in spontaneously hypertensive rats. J Cardiovasc Pharmacol 20:895-9 (1992). Read more (PubMed: 1282591) »
  • Morimoto S  et al. Effects of manidipine hydrochloride on proliferation and glycosaminoglycan synthesis of cultured vascular smooth muscle cells. Blood Press Suppl 3:27-9 (1992). Read more (PubMed: 1343285) »

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