Overview

  • Product name

    Manoalide, phospholipase C (PLC) inhibitor
  • Description

    Irreversible phospholipase C (PLC) inhibitor
  • Biological description

    Irreversible phospholipase C (PLC) and phospholipase A2 (PLA2) inhibitor (IC50 values are 1.5 and 4.7 µM respectively) . Also shown to inhibit calcium channels. Anti-inflammatory and analgesic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    75088-80-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Glaser KB  et al. Manoalide: structure-activity studies and definition of the pharmacophore for phospholipase A2 inactivation. Mol Pharmacol 36:782-8 (1989). Read more (PubMed: 2586492) »
  • Bennett CF  et al. Differential effects of manoalide on secreted and intracellular phospholipases. Biochem Pharmacol 36:733-40 (1987). Read more (PubMed: 3103628) »
  • Bennett CF  et al. Inhibition of phosphoinositide-specific phospholipase C by manoalide. Mol Pharmacol 32:587-93 (1987). Read more (PubMed: 3683364) »
  • Wheeler LA  et al. Manoalide, a natural sesterterpenoid that inhibits calcium channels. J Biol Chem 262:6531-8 (1987). Read more (PubMed: 2437121) »
See 1 Publication for this product

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