Mant-GTP (aqueous solution), Fluorescent nucleotide GTP analog (ab146757)

Overview

  • Product name

    Mant-GTP (aqueous solution), Fluorescent nucleotide GTP analog
  • Description

    Fluorescent nucleotide GTP analog
  • Biological description

    Fluorescent nucleotide GTP analog. The fluorescence is sensitive to the hydrophobicity of the environment. Exists in equilibrium as a mixture of C2'- and C3'-substituted isomers. Induces archaeal FtsZ polymerization into inactive curved filaments that cannot hydrolyze the nucleotide. Undergoes hydrolysis by proteins such as Obg. Competes with GTP for Era hydrolysis.
  • Purity

    > 95%
  • CAS Number

    148821-03-8
  • Chemical structure

    Chemical Structure

Properties

  • Excitation

    355nm
  • Emission

    448nm
  • Molecular weight

    656.33
  • Molecular formula

    C18H23N6O15P3
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Supplied in water (10 mM)
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • De Laurentiis EI & Wieden HJ Identification of two structural elements important for ribosome-dependent GTPase activity of elongation factor 4 (EF4/LepA). Sci Rep 5:8573 (2015). Read more (PubMed: 25712150) »
  • Zielke RA  et al. The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target. BMC Microbiol 15:129 (2015). Read more (PubMed: 26122105) »
  • Huecas S  et al. Beyond a Fluorescent Probe: Inhibition of Cell Division Protein FtsZ by mant-GTP Elucidated by NMR and Biochemical Approaches. ACS Chem Biol : (2015). Read more (PubMed: 26247422) »

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