Mant-GTPgammaS (aqueous solution), adenylyl cyclase inhibitor (ab146758)

Overview

  • Product name

    Mant-GTPgammaS (aqueous solution), adenylyl cyclase inhibitor
  • Description

    Potent, competitve adenylyl cyclase inhibitor. Fluorescent GTP derivative. eIF5B substrate.
  • Biological description

    Potent, competitive adenylyl cyclase inhibitor. Fluorescent GTP-γ-S (ab146662) derivative. eIF5B substrate. Noncompetitively inhibits GTP-γ-S-stimulated adenylyl cyclase in Galpha(s)-expressing Sf9 insect cell membranes.
  • Purity

    > 90%
  • CAS Number

    136749-24-1
  • Chemical structure

    Chemical Structure

Properties

  • Excitation

    355nm
  • Emission

    448nm
  • Molecular weight

    672.39
  • Molecular formula

    C18H23N6O14P3S
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Supplied in water (10 mM)
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Rottlaender D  et al. Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[gamma-thio]triphosphate. J Pharmacol Exp Ther 321:608-15 (2007). Read more (PubMed: 17284671) »
  • Pisareva VP  et al. Kinetic analysis of the interaction of guanine nucleotides with eukaryotic translation initiation factor eIF5B. Biochemistry 46:2622-9 (2007). Read more (PubMed: 17297921) »
  • Gille A & Seifert R MANT-substituted guanine nucleotides: a novel class of potent adenylyl cyclase inhibitors. Life Sci 74:271-9 (2003). Read more (PubMed: 14607255) »

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