Overview

  • Product name

    Anti-MAP2 antibody [MT-08]
    See all MAP2 primary antibodies
  • Description

    Mouse monoclonal [MT-08] to MAP2
  • Host species

    Mouse
  • Tested applications

    Suitable for: WB, IP, ELISA, IHC-P, IHC-Fr, ICCmore details
  • Species reactivity

    Reacts with: Cow, Human
    Predicted to work with: Mouse, Pig
  • Immunogen

    Full length native protein (purified) corresponding to Cow MAP2 aa 1375-1395.

  • Positive control

    • Human Cortex tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab118898 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 199 kDa.
IP Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
IHC-Fr Use at an assay dependent concentration.
ICC Use at an assay dependent concentration.

Target

  • Function

    The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
  • Sequence similarities

    Contains 3 Tau/MAP repeats.
  • Post-translational
    modifications

    Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67.
  • Cellular localization

    Cytoplasm, cytoskeleton.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp686I2148 antibody
    • MAP 2 antibody
    • MAP dendrite specific antibody
    • MAP-2 antibody
    • MAP2 antibody
    • MAP2A antibody
    • MAP2B antibody
    • MAP2C antibody
    • Microtubule associated protein 2 antibody
    • Microtubule-associated protein 2 antibody
    • MTAP2_HUMAN antibody
    see all

Images

  • ab118898 at 10ug/ml staining MAP2 in Formalin-fixed, Paraffin-embedded Human Cortex tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase -streptavidin and chromagen.

References

ab118898 has not yet been referenced specifically in any publications.

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