Overview

  • Product name

  • Description

    Goat polyclonal to MAP4K1/HPK1
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human MAP4K1/HPK1 aa 2-14 (N terminal).
    Sequence:

    DVVDPDIFNRDPR-C


    (Peptide available as ab22926)

  • Positive control

    • Jurkat lysate.
  • General notes

    GenBank Accession Number – NP_009112.

     This product was previously labelled as MAP4K1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab2646 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 95-100 kDa (predicted molecular weight: 95 kDa).

Target

  • Function

    May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation.
  • Tissue specificity

    Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine.
  • Sequence similarities

    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 CNH domain.
    Contains 1 protein kinase domain.
  • Information by UniProt
  • Database links

  • Alternative names

    • Hematopoietic progenitor kinase 1 antibody
    • Hematopoietic progenitor kinase antibody
    • HPK1 antibody
    • Human Hematopoietic Progenitor Kinase antibody
    • M4K1_HUMAN antibody
    • Map4k1 antibody
    • MAPK/ERK kinase kinase kinase 1 antibody
    • MEK kinase kinase 1 antibody
    • MEKKK 1 antibody
    • Mitogen activated protein kinase kinase kinase kinase 1 antibody
    • Mitogen-activated protein kinase kinase kinase kinase 1 antibody
    see all

Images

  • ab2646 staining (0.5µg/ml) of Jurkat lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. ab2646 staining (0.5µg/ml) of Jurkat lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence

References

This product has been referenced in:

  • Wang Y  et al. hsa-miR-96 up-regulates MAP4K1 and IRS1 and may function as a promising diagnostic marker in human bladder urothelial carcinomas. Mol Med Rep 5:260-5 (2012). Read more (PubMed: 21993544) »
See 1 Publication for this product

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