Overview

  • Product name

  • Description

    Rabbit polyclonal to MAS1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Fusion protein corresponding to Human MAS1 (internal sequence). (BC110454. The identity of the protein fusion partner is GST).
    Database link: P04201

  • Positive control

    • Human colon and liver cancer tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab197992 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.

Target

  • Function

    Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
  • Involvement in disease

    The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • MAS antibody
    • MAS proto oncogene antibody
    • Mas-related G protein-coupled receptor A antibody
    • MAS_HUMAN antibody
    • Mas1 antibody
    • MAS1 oncogene antibody
    • MAS1 proto-oncogene, G protein-coupled receptor antibody
    • MGRA antibody
    • Proto-oncogene Mas antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling MAS1 with ab197992 at 1/50 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling MAS1 with ab197992 at 1/50 dilution.

References

This product has been referenced in:

  • Ruan X  et al. Suxiao Jiuxin Pill protects cardiomyocytes against mitochondrial injury and alters gene expression during ischemic injury. Exp Ther Med 14:3523-3532 (2017). Read more (PubMed: 29042943) »
See 1 Publication for this product

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