The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-MAS1 antibody (ab66030)
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Preparation and Storage
Stability and Storage
Shipped at 4°C.
Reconstitute with 100uL sterile PBS.
MAS proto oncogene
Mas-related G protein-coupled receptor A
MAS1 proto-oncogene, G protein-coupled receptor
Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
Involvement in disease
The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.
Belongs to the G-protein coupled receptor 1 family.