Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab150298 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-MAS1 antibody (ab66030)

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C.

    Constituent: PBS

  • Reconstitution
    Reconstitute with 100uL sterile PBS.

General Info

  • Alternative names
    • MAS
    • MAS proto oncogene
    • Mas-related G protein-coupled receptor A
    • MAS_HUMAN
    • Mas1
    • MAS1 oncogene
    • MAS1 proto-oncogene, G protein-coupled receptor
    • MGRA
    • Proto-oncogene Mas
    see all
  • Function
    Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
  • Involvement in disease
    The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

References

ab150298 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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