Anti-MASS1 antibody (ab115621)
Key features and details
- Rabbit polyclonal to MASS1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-MASS1 antibody -
Description
Rabbit polyclonal to MASS1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide derived from the N terminal extracellular domain of Human MASS1.
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Positive control
- Human Brain cortex and Lung (respiratory epithelium) tissues.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -80°C. -
Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab115621 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 5 - 10 µg/ml. Formalin-fixed Paraffin-embedded tissues requires pretreatment with Proteinase K.
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Notes |
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IHC-P
Use a concentration of 5 - 10 µg/ml. Formalin-fixed Paraffin-embedded tissues requires pretreatment with Proteinase K. |
Target
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Function
Receptor that may have an important role in the development of the central nervous system. -
Tissue specificity
Expressed at low levels in adult tissues. -
Involvement in disease
Defects in GPR98 are the cause of Usher syndrome type 2C (USH2C) [MIM:605472]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses.
Defects in GPR98 may be a cause of familial febrile convulsions type 4 (FEB4) [MIM:604352]; also known as familial febrile seizures 4. Febrile convulsions are seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. -
Sequence similarities
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 35 Calx-beta domains.
Contains 6 EAR repeats.
Contains 1 GPS domain. -
Developmental stage
Isoform 1 is 4 times more abundant than isoform 2 in most tissues tested, despite wide variations in absolute levels of expression. Isoform 3 is expressed at about 1.5 times isoform 1 levels in most tissues examined. In fetal testis, isoform 3 is expressed almost exclusively. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 84059 Human
- Omim: 602851 Human
- SwissProt: Q8WXG9 Human
- Unigene: 591777 Human
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Alternative names
- DKFZp761P0710 antibody
- FEB 4 antibody
- FEB4 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab115621 has not yet been referenced specifically in any publications.