Key features and details
- Rabbit polyclonal to MASS1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-MASS1 antibody
DescriptionRabbit polyclonal to MASS1
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Synthetic peptide derived from the N terminal extracellular domain of Human MASS1.
- Human Brain cortex and Lung (respiratory epithelium) tissues.
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Storage instructionsShipped at 4°C. Store at -80°C.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab115621 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 5 - 10 µg/ml. Formalin-fixed Paraffin-embedded tissues requires pretreatment with Proteinase K.|
FunctionReceptor that may have an important role in the development of the central nervous system.
Tissue specificityExpressed at low levels in adult tissues.
Involvement in diseaseDefects in GPR98 are the cause of Usher syndrome type 2C (USH2C) [MIM:605472]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses.
Defects in GPR98 may be a cause of familial febrile convulsions type 4 (FEB4) [MIM:604352]; also known as familial febrile seizures 4. Febrile convulsions are seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.
Sequence similaritiesBelongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 35 Calx-beta domains.
Contains 6 EAR repeats.
Contains 1 GPS domain.
Developmental stageIsoform 1 is 4 times more abundant than isoform 2 in most tissues tested, despite wide variations in absolute levels of expression. Isoform 3 is expressed at about 1.5 times isoform 1 levels in most tissues examined. In fetal testis, isoform 3 is expressed almost exclusively.
Cellular localizationCell membrane.
- Information by UniProt
- DKFZp761P0710 antibody
- FEB 4 antibody
- FEB4 antibody
ab115621 has not yet been referenced specifically in any publications.