Overview

  • Product name

    Anti-MASS1 antibody - N-terminal
    See all MASS1 primary antibodies
  • Description

    Rabbit polyclonal to MASS1 - N-terminal
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except ANXA3 (50%).
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Horse, Dog, Monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to Human MASS1 (N terminal). 20 amino acids.
    Database link: Q8WXG9

  • Positive control

    • Human kidney, renal tubules tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab188940 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 4 - 9 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Receptor that may have an important role in the development of the central nervous system.
  • Tissue specificity

    Expressed at low levels in adult tissues.
  • Involvement in disease

    Defects in GPR98 are the cause of Usher syndrome type 2C (USH2C) [MIM:605472]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses.
    Defects in GPR98 may be a cause of familial febrile convulsions type 4 (FEB4) [MIM:604352]; also known as familial febrile seizures 4. Febrile convulsions are seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
    Contains 35 Calx-beta domains.
    Contains 6 EAR repeats.
    Contains 1 GPS domain.
  • Developmental stage

    Isoform 1 is 4 times more abundant than isoform 2 in most tissues tested, despite wide variations in absolute levels of expression. Isoform 3 is expressed at about 1.5 times isoform 1 levels in most tissues examined. In fetal testis, isoform 3 is expressed almost exclusively.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp761P0710 antibody
    • FEB 4 antibody
    • FEB4 antibody
    • G protein coupled receptor 98 antibody
    • G-protein coupled receptor 98 antibody
    • GPR 98 antibody
    • GPR98 antibody
    • GPR98_HUMAN antibody
    • KIAA0686 antibody
    • MASS 1 antibody
    • Monogenic audiogenic seizure susceptibility 1 homolog antibody
    • Monogenic audiogenic seizure susceptibility protein 1 homolog antibody
    • USH 2B antibody
    • USH 2C antibody
    • USH2B antibody
    • USH2C antibody
    • Usher syndrome 2C antibody
    • Usher syndrome type 2C protein antibody
    • Usher syndrome type-2C protein antibody
    • Very large G protein coupled receptor antibody
    • Very large G protein coupled receptor 1 antibody
    • Very large G-protein coupled receptor 1 antibody
    • VLGR 1 antibody
    • VLGR 1b antibody
    • VLGR1 antibody
    • VLGR1b antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney, renal tubules tissue labeling MASS1 with ab188940 at 9 µg/ml.

References

ab188940 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab188940.
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