Key features and details
- Goat polyclonal to Mast Cell Chymase
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Mast Cell Chymase antibody
See all Mast Cell Chymase primary antibodies
DescriptionGoat polyclonal to Mast Cell Chymase
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
- Human testis and tonsil tissue
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab111239 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 1.5 - 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionMajor secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Tissue specificityMast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions.
Sequence similaritiesBelongs to the peptidase S1 family. Granzyme subfamily.
Contains 1 peptidase S1 domain.
Cellular localizationSecreted. Cytoplasmic granule. Mast cell granules.
- Information by UniProt
- Alpha-chymase antibody
- Chymase 1 antibody
- Chymase 1 mast cell antibody
ab111239, at 1.5 µg/ml, staining Mast Cell Chymase in formalin fixed, paraffin embedded Human testis tissue by Immunohistochemistry. Biotinylated secondary antibody, followed by alkaline phosphatase streptavidin and chromogen were used to develop staining.
ab111239, at 1.5 µg/ml, staining Mast Cell Chymase in formalin fixed, paraffin embedded Human tonsil tissue by Immunohistochemistry. Biotinylated secondary antibody, followed by alkaline phosphatase streptavidin and chromogen were used to develop staining.
ab111239 has been referenced in 5 publications.
- Trias E et al. Schwann cells orchestrate peripheral nerve inflammation through the expression of CSF1, IL-34, and SCF in amyotrophic lateral sclerosis. Glia 68:1165-1181 (2020). PubMed: 31859421
- Valero-Jiménez A et al. Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF lungs and increases the fibrotic response in bleomycin-induced lung injury. PLoS One 13:e0192963 (2018). PubMed: 29529050
- Trias E et al. Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS. JCI Insight 3:N/A (2018). PubMed: 30282815
- Judd LM et al. Elevated IL-33 expression is associated with pediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis development in mice. Am J Physiol Gastrointest Liver Physiol 310:G13-25 (2016). Mouse . PubMed: 26514775
- Buzzelli JN et al. IL33 Is a Stomach Alarmin That Initiates a Skewed Th2 Response to Injury and Infection. Cell Mol Gastroenterol Hepatol 1:203-221.e3 (2015). PubMed: 28210674