• Product name
  • Description
    Rabbit polyclonal to Matrin 3
  • Host species
  • Tested applications
    Suitable for: IHC-P, IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Mouse, Human, Xenopus laevis
    Predicted to work with: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus
  • Immunogen

    Synthetic peptide corresponding to a region between residues 475 and 500 of human Matrin 3 (NP_061322.2)

  • Positive control
    • HeLa whole cell lysate.



Our Abpromise guarantee covers the use of ab70336 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1000 - 1/5000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
IP Use at 1-4 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.
    • Involvement in disease
      Defects in MATR3 are the cause of myopathy distal type 2 (MPD2) [MIM:606070]; also called vocal cord and pharyngeal dysfunction with distal myopathy (VCPDM). MPD2 is a muscular disorder characterized by distal weakness, with onset in hands and feet, associated with vocal cord and pharyngeal weakness causing a nasal voice and swallowing disorders.
    • Sequence similarities
      Contains 1 matrin-type zinc finger.
      Contains 2 RRM (RNA recognition motif) domains.
    • Cellular localization
      Nucleus matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • ALS21 antibody
      • KIAA0723 antibody
      • Matr3 antibody
      • MATR3_HUMAN antibody
      • Matrin-3 antibody
      • Matrin3 antibody
      • MPD2 antibody
      • VCPDM antibody
      • Vocal cord and pharyngeal weakness with distal myopathy antibody
      see all


    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human laryengeal squamous cell carcinoma (left) and mouse squamous cell carcinoma (right) tissues labelling Matrin 3 with ab70336 at 1/1000 (1µg/ml). Detection: DAB.
    • Detection of Human Matrin 3 by Western Blot of Immunprecipitate. Lane 1: HeLa whole cell lysates immunoprecipitated using ab70336 at 3µg/mg lysate (1 mg/IP; 1/4 of IP loaded/lane). Lane 2: an irrelevant antibody was used for immunoprecipitation. All lanes: ab70336 at 3µg/ml. Detection: Chemiluminescence with an exposure time of 3 seconds.


    This product has been referenced in:
    • Boehringer A  et al. ALS Associated Mutations in Matrin 3 Alter Protein-Protein Interactions and Impede mRNA Nuclear Export. Sci Rep 7:14529 (2017). Read more (PubMed: 29109432) »
    • Quintero-Rivera F  et al. MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus. Hum Mol Genet 24:2375-89 (2015). WB . Read more (PubMed: 25574029) »

    See all 3 Publications for this product

    Customer reviews and Q&As

    Thank you very much for letting me know.

    I wish you all the best with your experiments and look forward to hearing how you get on.

    Thank you for confirming those details. I have now set up a new delivery for you to the address which you specified. This should be with you tomorrow, or at the latest Friday. The order number is xxxx (PO number FOCR xxxxx).

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    I can understand why you would like to test both antibodies at the same time, and therefore I am willing to offer you this as a goodwill gesture. In order to do this I will need the original order number...

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    Thank you for contacting us and I'm sorry in the delay in getting back to you.

    As discussed over the phone yesterday, I am seeking more information from the source of this antibody to ascertain exactly why ab70336 was not deemed suitable for ...

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    Abcam guarantees this product to work in the species/application used in this Abreview.
    Human Cell lysate - whole cell (293T)
    Total protein in input
    10 µg
    Immuno-precipitation step
    Protein A/G

    Dr. Alessandro Marcello

    Verified customer

    Submitted Sep 30 2011


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