Anti-Matriptase 2 antibody (ab56181)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-Matriptase 2 antibody
See all Matriptase 2 primary antibodies -
Description
Rabbit polyclonal to Matriptase 2 -
Host species
Rabbit -
Specificity
ab56181 reacts with human Matripase 2 (TMPRSS6), and does not react with the other TMPRSSs. ab56181 recognizes all but the two truncated forms of Matripase 2. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human Matriptase 2. Synthetic peptide based on the CUB-2 domain of Matripase 2.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol, 2.9% Sodium chloride, PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab56181 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB |
Application notes
WB: 1/1000 when using colorimetric substrates such as BCIP/NBT, and 1/5000 for chemiluminescent substrates. Predicted molecular weight: 89 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Function
Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter. -
Tissue specificity
Liver specific. -
Involvement in disease
Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA) [MIM:206200]; also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron. -
Sequence similarities
Belongs to the peptidase S1 family.
Contains 2 CUB domains.
Contains 3 LDL-receptor class A domains.
Contains 1 peptidase S1 domain. -
Domain
Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s). -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 164656 Human
- Omim: 609862 Human
- SwissProt: Q8IU80 Human
- Unigene: 370885 Human
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Alternative names
- IRIDA antibody
- Matriptase-2 antibody
- Membrane bound mosaic serine proteinase matriptase 2 antibody
see all
Images
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Western blot - Anti-Matriptase 2 antibody (ab56181)All lanes : Anti-Matriptase 2 antibody (ab56181) at 1/1000 dilution
All lanes : Cell media from human embryonic kidney HEK293 cells
Predicted band size: 89 kDa
Protocols
Datasheets and documents
References
ab56181 has not yet been referenced specifically in any publications.
