Overview

  • Product name

    Maurocalcine, RyR1 agonist
  • Description

    Cell-permeable, reversible RyR1 agonist
  • Biological description

    Cell-permeable, reversible RyR1 agonist. Reversibly modifies channel gating behaviour of RyR1. Highly competitive cell-penetrating peptide. Induces intracellular Ca2+ release.
  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    3864.00
  • Molecular formula

    C156H260N56O46S6
  • Sequence

    GDCLPHLKRCKADNDCCGKKCKRRGTNAEKRCR (Modifications: Disulfide bonds: 3-17, 10-21, 16-32)
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Scorpio maurus palmatus

  • Research areas

Images

  • Maurocalcine evokes long lasting Ca2+ release events in skeletal myotubes.

    Myotube cell cultures were prepared from limbs of 2 days old rat pups were loaded with 4 mM fluo-3 AM (ab145254) and then stimulated with Maurocalcine (ab141860). Ca2+ spreads in the same myotube before (A) and after (B) stimulation with 200 nM Maurocalcine.

References

This product has been referenced in:

  • Poillot C  et al. Small efficient cell-penetrating peptides derived from scorpion toxin maurocalcine. J Biol Chem 287:17331-42 (2012). Read more (PubMed: 22433862) »
  • Fajloun Z  et al. Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca(2+) release channel/ryanodine receptors. FEBS Lett 469:179-85 (2000). Read more (PubMed: 10713267) »
  • Csernoch L  et al. Voltage-activated elementary calcium release events in isolated mouse skeletal muscle fibers. J Membr Biol 226:43-55 (0). Read more (PubMed: 19015802) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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