Key features and details
- Cell-permeable, reversible RyR1 agonist
- CAS Number:
- Purity: > 98%
- Soluble in water
- Form / State: Solid
- Source: Scorpio maurus palmatus
Product nameMaurocalcine, RyR1 agonist
DescriptionCell-permeable, reversible RyR1 agonist
Biological descriptionCell-permeable, reversible RyR1 agonist. Reversibly modifies channel gating behaviour of RyR1. Highly competitive cell-penetrating peptide. Induces intracellular Ca2+ release.
SequenceGDCLPHLKRCKADNDCCGKKCKRRGTNAEKRCR (Modifications: Disulfide bonds: 3-17, 10-21, 16-32)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Scorpio maurus palmatus
2D chemical structure image of ab141860, Maurocalcine, RyR1 agonist
Maurocalcine evokes long lasting Ca2+ release events in skeletal myotubes.
Myotube cell cultures were prepared from limbs of 2 days old rat pups were loaded with 4 mM fluo-3 AM (ab145254) and then stimulated with Maurocalcine (ab141860). Ca2+ spreads in the same myotube before (A) and after (B) stimulation with 200 nM Maurocalcine.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141860 has been referenced in 1 publication.
- Duan J et al. The cell-wide web coordinates cellular processes by directing site-specific Ca2+ flux across cytoplasmic nanocourses. Nat Commun 10:2299 (2019). PubMed: 31127110