Overview

  • Product name

    Anti-MAVS antibody - N-terminal
    See all MAVS primary antibodies
  • Description

    Rabbit polyclonal to MAVS - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IF, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human MAVS (N terminal). 13 amino acid peptide.
    Database link: Q7Z434

  • Positive control

    • Human thymus tissue. Human brain cells. A20 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab189303 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 57 kDa.

Target

  • Function

    Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
  • Tissue specificity

    Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
  • Sequence similarities

    Contains 1 CARD domain.
  • Domain

    Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58 and IFIH1.
  • Post-translational
    modifications

    Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS proteasomal degradation.
  • Cellular localization

    Mitochondrion outer membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CARD adapter inducing interferon beta antibody
    • CARD adaptor inducing IFN beta antibody
    • Cardif antibody
    • DKFZp666M015 antibody
    • FLJ27482 antibody
    • FLJ41962 antibody
    • IFN B promoter stimulator 1 antibody
    • Interferon beta promoter stimulator protein 1 antibody
    • Ips 1 antibody
    • IPS-1 antibody
    • Ips1 antibody
    • KIAA1271 antibody
    • MAVS antibody
    • MAVS_HUMAN antibody
    • Mitochondrial anti viral signaling protein antibody
    • Mitochondrial Antiviral Signaling antibody
    • Mitochondrial antiviral signaling protein antibody
    • Mitochondrial antiviral-signaling protein antibody
    • Putative NF kappa B activating protein 031N antibody
    • Putative NF-kappa-B-activating protein 031N antibody
    • Virus induced signaling adapter antibody
    • virus induced signaling adaptor antibody
    • Virus-induced-signaling adapter antibody
    • VISA antibody
    see all

Images

  • Lane 1 : Anti-MAVS antibody - N-terminal (ab189303) at 0.5 µg/ml
    Lane 2 : Anti-MAVS antibody - N-terminal (ab189303) at 1 µg/ml
    Lane 3 : Anti-MAVS antibody - N-terminal (ab189303) at 2 µg/ml

    All lanes : A20 cell lysate

    Predicted band size: 57 kDa

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human thymus tissue, labeling MAVS with ab189303 at 5 µg/ml.

  • Immunofluorescent analysis of human brain cells, labeling MAVS with ab189303 at 20 µg/ml.

References

ab189303 has not yet been referenced specifically in any publications.

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