Overview

  • Product name

    Anti-Maxi Potassium channel beta/KCNMB1 antibody
    See all Maxi Potassium channel beta/KCNMB1 primary antibodies
  • Description

    Rabbit polyclonal to Maxi Potassium channel beta/KCNMB1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rabbit
  • Immunogen

    Recombinant fragment corresponding to Human Maxi Potassium channel beta/KCNMB1 aa 1-191.

  • Positive control

    • 293T, A431, H1299, HeLa, HepG2, MOLT4, Raji and mouse heart lysates.
  • General notes

     This product was previously labelled as Maxi Potassium channel beta

     

Properties

Applications

Our Abpromise guarantee covers the use of ab154421 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 22 kDa.

Target

  • Function

    Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
  • Tissue specificity

    Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.
  • Sequence similarities

    Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.
  • Post-translational
    modifications

    N-glycosylated.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • BK channel beta subunit antibody
    • BK channel subunit beta 1 antibody
    • BK channel subunit beta-1 antibody
    • BKbeta antibody
    • BKbeta1 antibody
    • Calcium activated potassium channel subfamily M subunit beta 1 antibody
    • Calcium activated potassium channel subunit beta 1 antibody
    • Calcium activated potassium channel subunit beta antibody
    • Calcium-activated potassium channel antibody
    • Calcium-activated potassium channel subunit beta antibody
    • Calcium-activated potassium channel subunit beta-1 antibody
    • Charybdotoxin receptor subunit beta 1 antibody
    • Charybdotoxin receptor subunit beta-1 antibody
    • Hbeta1 antibody
    • hslo beta antibody
    • K(VCA)beta 1 antibody
    • K(VCA)beta antibody
    • K(VCA)beta-1 antibody
    • KCMB1_HUMAN antibody
    • KCNMB 1 antibody
    • Kcnmb1 antibody
    • Large conductance Ca2+ activated K+ channel beta 1 subunit antibody
    • Maxi K channel beta subunit antibody
    • Maxi K channel subunit beta 1 antibody
    • Maxi K channel subunit beta-1 antibody
    • Potassium large conductance calcium activated channel subfamily M beta member 1 antibody
    • Slo beta 1 antibody
    • SLO beta antibody
    • Slo-beta antibody
    • Slo-beta-1 antibody
    • subfamily M subunit beta-1 antibody
    see all

Images

  • Anti-Maxi Potassium channel beta/KCNMB1 antibody (ab154421) at 1/10000 dilution + Mouse heart whole cell lysate at 50 µg

    Predicted band size: 22 kDa



    12% SDS PAGE
  • All lanes : Anti-Maxi Potassium channel beta/KCNMB1 antibody (ab154421) at 1/1000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : H1299 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 22 kDa



    12% SDS PAGE

References

ab154421 has not yet been referenced specifically in any publications.

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