Description

Specifications

Our Abpromise guarantee covers the use of ab5023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Lyophilised
  • Additional notes

    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human Maxi K+ beta, catalog ab5023. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

     This product was previously labelled as Maxi Potassium channel beta

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • Reconstitution
    >95% pure, lyophilized synthetic peptide. Reconstitute with 0.1 ml of distilled water.

General Info

  • Alternative names

    • BK channel beta subunit
    • BK channel subunit beta 1
    • BK channel subunit beta-1
    • BKbeta
    • BKbeta1
    • Calcium activated potassium channel subfamily M subunit beta 1
    • Calcium activated potassium channel subunit beta
    • Calcium activated potassium channel subunit beta 1
    • Calcium-activated potassium channel
    • Calcium-activated potassium channel subunit beta
    • Calcium-activated potassium channel subunit beta-1
    • Charybdotoxin receptor subunit beta 1
    • Charybdotoxin receptor subunit beta-1
    • Hbeta1
    • hslo beta
    • K(VCA)beta
    • K(VCA)beta 1
    • K(VCA)beta-1
    • KCMB1_HUMAN
    • KCNMB 1
    • Kcnmb1
    • Large conductance Ca2+ activated K+ channel beta 1 subunit
    • Maxi K channel beta subunit
    • Maxi K channel subunit beta 1
    • Maxi K channel subunit beta-1
    • Potassium large conductance calcium activated channel subfamily M beta member 1
    • SLO beta
    • Slo beta 1
    • Slo-beta
    • Slo-beta-1
    • subfamily M subunit beta-1
    see all
  • Function

    Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
  • Tissue specificity

    Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.
  • Sequence similarities

    Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.
  • Post-translational
    modifications

    N-glycosylated.
  • Cellular localization

    Membrane.
  • Information by UniProt

References

This product has been referenced in:

  • Navarro-Antolín J  et al. Decreased expression of maxi-K+ channel beta1-subunit and altered vasoregulation in hypoxia. Circulation 112:1309-15 (2005). Read more (PubMed: 16116057) »
See 1 Publication for this product

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