Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferConstituent: PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab26848 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||Use at an assay dependent dilution.|
FunctionBinds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Tissue specificityHighly expressed in brain, heart, kidney, stomach, testis and placenta.
Sequence similaritiesContains 1 MBD (methyl-CpG-binding) domain.
Cellular localizationNucleus. Nuclear, in discrete foci. Detected at replication foci in late S phase.
- Information by UniProt
- Demethylase antibody
- DMTase antibody
- MBD 2 antibody
ab26848 has not yet been referenced specifically in any publications.