Overview

  • Product name

  • Description

    Rabbit polyclonal to MBD5
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ELISAmore details
  • Species reactivity

    Reacts with: Recombinant fragment
    Predicted to work with: Mouse, Human
  • Immunogen

    A synthetic peptide corresponding to C-terminal residues of human MBD5

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.01% Sodium azide
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab56126 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 160 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.

Target

  • Function

    Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
  • Tissue specificity

    Detected in heart, placenta, liver, skeletal muscle, kidney and pancreas.
  • Involvement in disease

    Defects in MBD5 are the cause of mental retardation autosomal dominant type 1 (MRD1) [MIM:156200]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
  • Sequence similarities

    Contains 1 MBD (methyl-CpG-binding) domain.
    Contains 1 PWWP domain.
  • Domain

    Both MBD and PWWP domains are necessary for chromocentric localization.
  • Cellular localization

    Nucleus. Chromosome. Associated with pericentric heterochromatin and Nucleus. Not associated with pericentric heterochromatin.
  • Information by UniProt
  • Database links

  • Alternative names

    • 9430004D19Rik antibody
    • AA536666 antibody
    • AI426407 antibody
    • C030040A15Rik antibody
    • FLJ11113 antibody
    • FLJ30517 antibody
    • KIAA1461 antibody
    • MBD5 antibody
    • MBD5_HUMAN antibody
    • methyl CpG binding domain protein 5 antibody
    • Methyl CpG binding protein MBD5 antibody
    • Methyl-CpG-binding domain protein 5 antibody
    • Methyl-CpG-binding protein MBD5 antibody
    • RP23 167N13.1 antibody
    see all

References

ab56126 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab56126.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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