Key features and details
- Rabbit polyclonal to MBNL3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-MBNL3 antibody
See all MBNL3 primary antibodies
DescriptionRabbit polyclonal to MBNL3
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Recombinant fragment, corresponding to a sequence within amino acids 1-267 of Human MBNL3.
- 293T, A431, HeLaS3, HepG2, Molt4 and Raji whole cell lysates.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab96179 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 39 kDa.|
FunctionMediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
Tissue specificityHighly expressed in the placenta.
Sequence similaritiesBelongs to the muscleblind family.
Contains 4 C3H1-type zinc fingers.
Cellular localizationNucleus. Cytoplasm. Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
- Information by UniProt
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ab96179 has not yet been referenced specifically in any publications.