Anti-MC1-R antibody [578CT6.2.3] (ab230675)

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Overview

  • Product name

    Anti-MC1-R antibody [578CT6.2.3]
    See all MC1-R primary antibodies

  • Description

    Mouse monoclonal [578CT6.2.3] to MC1-R

  • Host species

    Mouse

  • Tested applications

    Suitable for: WB, IHC-Pmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Cat, Chimpanzee, Gorilla

  • Immunogen

    Synthetic peptide within Human MC1-R aa 205-232 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    VLYVHMLARACQHAQGIARLHKRQRPVH


    Database link: Q01726

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • WB: A-375 cell lysate. IHC-P: Human brain cortex tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab230675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/250. Predicted molecular weight: 35 kDa.
IHC-P 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

  • Tissue specificity

    Melanocytes and corticoadrenal tissue.

  • Involvement in disease

    Genetic variations in MC1R are a cause of susceptibility to cutaneous malignant melanoma type 5 (CMM5) [MIM:613099]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.

  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.

  • Cellular localization

    Cell membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • CMM5 antibody
      • MC1 Receptor antibody
      • MC1-R antibody
      • MC1R antibody
      • Melanocortin 1 receptor antibody
      • Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) antibody
      • Melanocortin receptor 1 antibody
      • Melanocyte-stimulating hormone receptor antibody
      • Melanotropin receptor antibody
      • MSH-R antibody
      • MSHR antibody
      • MSHR_HUMAN antibody
      • SHEP2 antibody
      see all

    Images

    • Western blot - Anti-MC1-R antibody [578CT6.2.3] (ab230675)
      Western blot - Anti-MC1-R antibody [578CT6.2.3] (ab230675)
      Anti-MC1-R antibody [578CT6.2.3] (ab230675) at 1/100 dilution + A-375 (human malignant melanoma cell line) cell lysate at 35 µg

      Predicted band size: 35 kDa

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MC1-R antibody [578CT6.2.3] (ab230675)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MC1-R antibody [578CT6.2.3] (ab230675)

      Formalin-fixed, paraffin-embedded human brain cortex tissue stained for MC1-R using ab230675 at 1/100 dilution in immunohistochemical analysis.

    References

    ab230675 has not yet been referenced specifically in any publications.

    Publishing research using ab230675? Please let us know so that we can cite the reference in this datasheet.

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