Key features and details
- Rabbit polyclonal to MC1-R
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-MC1-R antibody
See all MC1-R primary antibodies
DescriptionRabbit polyclonal to MC1-R
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
- Molt4 whole cell lysate; 293T, HeLa and Raji cells
Previously labelled as MC1 Receptor.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab97321 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 35 kDa.|
FunctionReceptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Tissue specificityMelanocytes and corticoadrenal tissue.
Involvement in diseaseGenetic variations in MC1R are a cause of susceptibility to cutaneous malignant melanoma type 5 (CMM5) [MIM:613099]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Cellular localizationCell membrane.
- Information by UniProt
- CMM5 antibody
- MC1 Receptor antibody
- MC1-R antibody
ab97321 has been referenced in 1 publication.
- Simamura E et al. Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. PLoS One 10:e0123232 (2015). PubMed: 25860801