Anti-MC2-R antibody (ab135908)
Key features and details
- Rabbit polyclonal to MC2-R
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-MC2-R antibody
See all MC2-R primary antibodies -
Description
Rabbit polyclonal to MC2-R -
Host species
Rabbit -
Specificity
Detects endogenous levels of MC2-R. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide corresponding to Human MC2-R (C terminal).
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Positive control
- COLO205 cell lysates
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General notes
Protein previously labeled as MC2 receptor.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20ºC. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49.1% PBS, 0.88% Sodium chloride
PBS without Mg2+ or Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
The antibody was affinity-purified from rabbit anti-serum by immunogenic peptide affinity-chromatography. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab135908 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | 1/500 - 1/1000. Predicted molecular weight: 34 kDa. |
Target
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Function
Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. -
Tissue specificity
Melanocytes and corticoadrenal tissue. -
Involvement in disease
Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 4158 Human
- Entrez Gene: 17200 Mouse
- Omim: 607397 Human
- SwissProt: Q01718 Human
- SwissProt: Q64326 Mouse
- Unigene: 248144 Human
- Unigene: 426053 Mouse
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Alternative names
- ACTH receptor antibody
- ACTH-R antibody
- ACTHR antibody
see all
Images
Datasheets and documents
References (0)
ab135908 has not yet been referenced specifically in any publications.