Anti-MC2-R antibody (ab135908)

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Western blot - Anti-MC2-R antibody (ab135908)

    Key features and details

    • Rabbit polyclonal to MC2-R
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-MC2-R antibody
      See all MC2-R primary antibodies

    • Description

      Rabbit polyclonal to MC2-R

    • Host species

      Rabbit

    • Specificity

      Detects endogenous levels of MC2-R.

    • Tested applications

      Suitable for: WBmore details

    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse

    • Immunogen

      Synthetic peptide corresponding to Human MC2-R (C terminal).

    • Positive control

      • COLO205 cell lysates

    • General notes

      Protein previously labeled as MC2 receptor.

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    Applications

    Our Abpromise guarantee covers the use of ab135908 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB 1/500 - 1/1000. Predicted molecular weight: 34 kDa.

    Target

    • Function

      Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.

    • Tissue specificity

      Melanocytes and corticoadrenal tissue.

    • Involvement in disease

      Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.

    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family.

    • Cellular localization

      Cell membrane.
    • Information by UniProt

    • Database links

      • Alternative names

        • ACTH receptor antibody
        • ACTH-R antibody
        • ACTHR antibody
        • ACTHR_HUMAN antibody
        • Adrenocorticotropic hormone receptor antibody
        • Adrenocorticotropin receptor antibody
        • Corticotropin receptor antibody
        • MC2 receptor antibody
        • MC2-R antibody
        • MC2R antibody
        • Melanocortin 2 receptor (adrenocorticotropic hormone) antibody
        • Melanocortin 2 receptor antibody
        • Melanocortin receptor 2 antibody
        see all

      Images

      • Western blot - Anti-MC2-R antibody (ab135908)
        Western blot - Anti-MC2-R antibody (ab135908)
        Anti-MC2-R antibody (ab135908) at 1/500 dilution + COLO205 cell lysate at 30 µg

        Predicted band size: 34 kDa

      References (0)

      Publishing research using ab135908? Please let us know so that we can cite the reference in this datasheet.

      ab135908 has not yet been referenced specifically in any publications.

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