Anti-MC2-R antibody (ab135908)

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Overview

  • Product name

    Anti-MC2-R antibody
    See all MC2-R primary antibodies

  • Description

    Rabbit polyclonal to MC2-R

  • Host species

    Rabbit

  • Specificity

    Detects endogenous levels of MC2-R.

  • Tested applications

    Suitable for: WBmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse

  • Immunogen

    Synthetic peptide corresponding to Human MC2-R (C terminal).

  • Positive control

    • COLO205 cell lysates

  • General notes

    Protein previously labeled as MC2 receptor.

Properties

Applications

Our Abpromise guarantee covers the use of ab135908 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 34 kDa.

Target

  • Function

    Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.

  • Tissue specificity

    Melanocytes and corticoadrenal tissue.

  • Involvement in disease

    Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.

  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.

  • Cellular localization

    Cell membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • ACTH receptor antibody
      • ACTH-R antibody
      • ACTHR antibody
      • ACTHR_HUMAN antibody
      • Adrenocorticotropic hormone receptor antibody
      • Adrenocorticotropin receptor antibody
      • Corticotropin receptor antibody
      • MC2 receptor antibody
      • MC2-R antibody
      • MC2R antibody
      • Melanocortin 2 receptor (adrenocorticotropic hormone) antibody
      • Melanocortin 2 receptor antibody
      • Melanocortin receptor 2 antibody
      see all

    Images

    • Western blot - Anti-MC2-R antibody (ab135908)
      Western blot - Anti-MC2-R antibody (ab135908)
      Anti-MC2-R antibody (ab135908) at 1/500 dilution + COLO205 cell lysate at 30 µg

      Predicted band size: 34 kDa

    References

    ab135908 has not yet been referenced specifically in any publications.

    Publishing research using ab135908? Please let us know so that we can cite the reference in this datasheet.

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