Anti-MC4-R antibody (ab106596)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-MC4-R antibody
See all MC4-R primary antibodies -
Description
Rabbit polyclonal to MC4-R -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, ICC/IF, WBmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide corresponding to Human MC4-R (N terminal).
Database link: NP_005903 -
Positive control
- Rat brain tissue lysate; Human brain tissue.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
Our Abpromise guarantee covers the use of ab106596 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | Use a concentration of 2.5 µg/ml. | |
| ICC/IF | Use a concentration of 20 µg/ml. | |
| WB | Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 37 kDa. |
Target
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Function
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase. -
Tissue specificity
Brain, placental, and gut tissues. -
Involvement in disease
Defects in MC4R are a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 4160 Human
- Entrez Gene: 17202 Mouse
- Entrez Gene: 25635 Rat
- Omim: 155541 Human
- SwissProt: P32245 Human
- SwissProt: P56450 Mouse
- SwissProt: P70596 Rat
- Unigene: 532833 Human
see all -
Alternative names
- MC4 Receptor antibody
- MC4-R antibody
- MC4R antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MC4-R antibody (ab106596)ab106596, at 2.5 µg/ml, staining MC4-R in Human brain tissue by Immunohistochemistry.
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Western blot - Anti-MC4-R antibody (ab106596)All lanes : Anti-MC4-R antibody (ab106596) at 1 µg/ml
Lane 1 : Rat brain tissue lysate
Lane 2 : Rat brain tissue lysate with blocking peptide
Lysates/proteins at 15 µg per lane.
Predicted band size: 37 kDa -
Immunocytochemistry/ Immunofluorescence - Anti-MC4-R antibody (ab106596)Immunofluorescence of MC4-R in Human Brain cells using ab106596 at 20 ug/ml.
Protocols
Datasheets and documents
References
ab106596 has not yet been referenced specifically in any publications.
