RecombinantRabMAb

Recombinant Anti-MC4-R antibody [EPR6534(2)(ABC)] (ab150419)

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Western blot - Anti-MC4-R antibody [EPR6534(2)(ABC)] (ab150419)
  • Anti-MC4-R antibody [EPR6534(2)(ABC)] (ab150419)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR6534(2)(ABC)] to MC4-R
  • Suitable for: WB
  • Reacts with: Mouse, Rat, Human

Overview

  • Product name

    Anti-MC4-R antibody [EPR6534(2)(ABC)]
    See all MC4-R primary antibodies

  • Description

    Rabbit monoclonal [EPR6534(2)(ABC)] to MC4-R

  • Host species

    Rabbit

  • Tested Applications & Species

    Application Species
    WB
    Human
    See all applications and species data

  • Immunogen

    Synthetic peptide within Human MC4-R aa 1-100 (C terminal). The exact sequence is proprietary.
    Database link: P32245

  • Positive control

    • 293T; MCF7; JAR; SH-SY5Y; C6; RAW 264.7; PC12 and NIH 3T3 cell lysates.

  • General notes

     

     

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab150419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
WB
Human
Application Abreviews Notes
WB
1/1000 - 1/10000. Predicted molecular weight: 36 kDa.
Notes
WB
1/1000 - 1/10000. Predicted molecular weight: 36 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

    • Target

    • Function

      Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.

    • Tissue specificity

      Brain, placental, and gut tissues.

    • Involvement in disease

      Defects in MC4R are a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family.

    • Cellular localization

      Cell membrane.
    • Information by UniProt

    • Database links

      see all

    • Alternative names

      • MC4 Receptor antibody
      • MC4-R antibody
      • MC4R antibody
      • MC4R_HUMAN antibody
      • Melanocortin 4 receptor antibody
      • Melanocortin receptor 4 antibody
      • MGC126851 antibody
      • MGC138197 antibody
      see all

    Images

    • Western blot - Anti-MC4-R antibody [EPR6534(2)(ABC)] (ab150419)
      Western blot - Anti-MC4-R antibody [EPR6534(2)(ABC)] (ab150419)
      All lanes : Anti-MC4-R antibody [EPR6534(2)(ABC)] (ab150419) at 1/1000 dilution

      Lane 1 : 293T cell lysate
      Lane 2 : MCF7 cell lysate
      Lane 3 : JAR cell lysate
      Lane 4 : SH-SY5Y cell lysate
      Lane 5 : C6 cell lysate
      Lane 6 : RAW 264.7 cell lysate
      Lane 7 : PC12 cell lysate
      Lane 8 : NIH 3T3 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 36 kDa

    • Anti-MC4-R antibody [EPR6534(2)(ABC)] (ab150419)
      Anti-MC4-R antibody [EPR6534(2)(ABC)] (ab150419)

    References (0)

    Publishing research using ab150419? Please let us know so that we can cite the reference in this datasheet.

    ab150419 has not yet been referenced specifically in any publications.

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