Recombinant
RabMAb

Recombinant Anti-MC4-R antibody [EPR6534(2)(ABC)] (ab150419)

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Overview

  • Product name

    Anti-MC4-R antibody [EPR6534(2)(ABC)]
    See all MC4-R primary antibodies

  • Description

    Rabbit monoclonal [EPR6534(2)(ABC)] to MC4-R

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP

  • Species reactivity

    Reacts with: Mouse, Rat, Human

  • Immunogen

    Synthetic peptide within Human MC4-R aa 1-100 (C terminal). The exact sequence is proprietary.
    Database link: P32245

  • Positive control

    • 293T; MCF7; JAR; SH-SY5Y; C6; RAW 264.7; PC12 and NIH 3T3 cell lysates.

  • General notes

     

     

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

Applications

Our Abpromise guarantee covers the use of ab150419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 36 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

    • Target

    • Function

      Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.

    • Tissue specificity

      Brain, placental, and gut tissues.

    • Involvement in disease

      Defects in MC4R are a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family.

    • Cellular localization

      Cell membrane.
    • Information by UniProt

    • Database links

      see all

    • Alternative names

      • MC4 Receptor antibody
      • MC4-R antibody
      • MC4R antibody
      • MC4R_HUMAN antibody
      • Melanocortin 4 receptor antibody
      • Melanocortin receptor 4 antibody
      • MGC126851 antibody
      • MGC138197 antibody
      see all

    Images

    • Western blot - Anti-MC4-R antibody [EPR6534(2)(ABC)] (ab150419)
      Western blot - Anti-MC4-R antibody [EPR6534(2)(ABC)] (ab150419)
      All lanes : Anti-MC4-R antibody [EPR6534(2)(ABC)] (ab150419) at 1/1000 dilution

      Lane 1 : 293T cell lysate
      Lane 2 : MCF7 cell lysate
      Lane 3 : JAR cell lysate
      Lane 4 : SH-SY5Y cell lysate
      Lane 5 : C6 cell lysate
      Lane 6 : RAW 264.7 cell lysate
      Lane 7 : PC12 cell lysate
      Lane 8 : NIH 3T3 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 36 kDa

    References

    ab150419 has not yet been referenced specifically in any publications.

    Publishing research using ab150419? Please let us know so that we can cite the reference in this datasheet.

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